Thursday 14 August 2025 | 15:35-16:05 

Format: Presentation

Stream: Safety

Part 1: Stories from the little red dot: A data driven approach to tackling Alert Fatigue in Electronic Medical Records

Singapore is currently transitioning to New Generation Electronic Medical Record (NGEMR), a unified system for all public healthcare institutions. During this transition, clinical decision support tools that were originally developed for individual institution was migrated in bulk to all institutions. This was causing frustration for users as they did not integrate well with clinical workflows and contributed to alert fatigue.

This presentation captures the Quality Improvement (QI) journey undertaken by the National University Health System (NUHS) in Singapore to transform its Clinical Decision Support system, focusing on our top firing Best Practice Advisories that contributed to the majority of alert fatigue. The goal was to enhance alert efficacy, reduce alert fatigue, and improve user experience by making it easier to do the right thing.

Jishana Farhad Abdul Naseer National University Health Systems; Singapore

Part 2: Implementing Cost-Effective Pharmacogenetics Service for Improving Patient Safety

Pharmacogenetics uses a person’s genetic information to inform if they may be under-dosed (i.e. therapeutic failure), overdosed (i.e. toxicity) or are at risk of adverse drug reactions. It is an important clinical tool for improving patient safety. Data from Singapore showed that about 30% of adverse drug reactions (ADRs) admitted to a major acute care hospital in Singapore were caused by at least one drug with a clinical annotation in the Pharmacogenomics KnowledgeBase (PharmGKB). Furthermore, the SG10K_Health study further revealed that 26.8% of Singaporeans carry a genetic variant that raises the risk of life-threatening side effects to at least one medication. This session will describe the processes for implementing a pharmacogenetic service across multiple acute care hospitals in Singapore, share the lessons learnt and discuss approaches to improve the cost-effectiveness of such a service, including identifying the subgroups of patients who will experience the greatest benefits.

Wee Hwee Lin Saw Swee Hock School of Public Health; Singapore